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Deterministic lateral displacement (DLD) is a microfluidic micro/nanopost array-based technique for size-based particle separations. A key challenge in scaling DLD for handling smaller particles is that creating such “nanoDLD” arrays can be cost-intensive with substantial technical hurdles. To circumvent such issues, here we explore a new “hexagonally arranged triangles (HAT)” DLD geometry that is based on patterns associated with nanosphere lithography (NSL). Finite element simulations and preliminary experiments with 0.86 μm and 4.7 μm particles suggest effective separation capabilities of the HAT-DLD approach, marking an important first step toward new classes of nanoDLD arrays fabricated through bottom-up, self-assembly-based NSL.more » « less
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